Abreva® Cream is a cold sore medicine that penetrates deep into the skin and starts to work immediately to block the virus. It is also the only nonprescription cold sore medicine approved by the FDA to shorten healing time, by getting to the source of your cold sore without stinging or burning. Abreva® Cream is a smooth, white cream that dries clear, and it has no smell or taste. You could knock out your cold sore in 2½ days when you use Abreva® Cream at the first sign of a cold sore.* *Median healing time 4.1 days. 25% of users healed in 2.5 days.